Tetrahydrofuran → HCID 20266223, compound

HRID 462376Notes

Reaction equation

HRID 462376 reaction equation
C[C:2]([CH3:5])([O-:4])[CH3:3].[Li+].[CH3:7][O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[O:15][CH:14]2S(C1C=CC=CC=1)(=O)=O.[CH2:28]1[CH2:32][O:31][CH2:30][CH2:29]1>>[C:2]([C:5]1[CH:11]=[C:10]2[C:9]([C:32](=[O:31])[C:28]3[CH:16]([OH:18])[CH:17]4[C:13](=[C:14]([OH:15])[C:29]=3[CH2:30]2)[CH2:12][CH2:11][CH2:10][CH:9]4[O:8][CH3:7])=[CH:17][CH:16]=1)(=[O:4])[CH3:3]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 109576723-(Benzenesulfonyl)-7-methoxy-2-benzofuran-1(3H)-oneHCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)

Product 1

HCID 20266223HCID 20266223, compound

Procedure

To a magnetically stirred solution of lithium t-butoxide (8.8 mmol, prepared from 8.8 mmol of n-BuLi and 9.0 mmol of t-BuOH in 100 mL of THF), cooled to -78° C., was slowly added a slurry of 7-methoxy-3-phenylsulfonyl-1-(3H)-isobenzofuranone (6) (0.91 g, 3 mmol) in THF (20 mL).

Sources & evidence

ORD record
ord-2bc1679eb84c4ab0acc3a12c7420ade9
Source dataset
uspto-grants-1985_05
Patent number
US04515720

Reaction notes

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