Phosphorus oxychloride → N-Cyclohexyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

HRID 4631Notes

Reaction equation

HRID 4631 reaction equation
[CH:1]1([NH:7][C:8]([NH:10][NH:11][C:12]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]3)[CH:20]=2)=[S:13])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[CH:1]1([NH:7][C:8]2[S:13][C:12]([NH:14][CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]4[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]4)[CH:20]=3)=[N:11][N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13657340N-cyclohexyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

Product 1

HCID 13657368N-Cyclohexyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 40 from N-cyclohexyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide and phosphorus oxychloride. The analytical values are summarized in Table III.

Sources & evidence

ORD record
ord-e67f7b9458324899aa2bf340325e6943
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

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