Potassium Carbonate → 1-[4-(4-Chlorophenyl)-2-methanesulfonyloxy-n-butyl]imidazole

HRID 463284Notes

Reaction equation

HRID 463284 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH:11]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])[CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+]>C(Cl)Cl>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][CH:11]([O:18][S:19]([CH3:22])(=[O:21])=[O:20])[CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 202825741-[4-(4-Chlorophenyl)-2-(methanesulfonyloxy)-n-butyl]imidazole hydrochloride

Product 1

HCID 202822431-[4-(4-Chlorophenyl)-2-methanesulfonyloxy-n-butyl]imidazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[4-(4-Chlorophenyl)-2-methanesulfonyloxy-n-butyl]imidazole hydrochloride (3.65 g) (prepared in Preparation 10) in methylene chloride (50 ml) was shaken with excess 10% aqueous potassium carbonate solution until no solid remained. The organic layer was separated, dried (MgSO4) and evaporated to give 1-[4-(4-chlorophenyl)-2-methanesulfonyloxy-n-butyl]imidazole as a solid.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-30ecff05fe8a4cde836f81e658ca5416
Source dataset
uspto-grants-1985_05
Patent number
US04518607

Reaction notes

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