Tetrahydrofuran → HCID 54247622, compound

HRID 463290Notes

Reaction equation

HRID 463290 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]([S:17][C:18]2[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=2)[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.[N-:25]=[C:26]=[S:27].O1CC[CH2:30][CH2:29]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]([S:17][C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:26]([NH:25][CH2:29][CH3:30])=[S:27])=[CH:22][CH:23]=2)[CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 13457330HCID 13457330, compoundHCID 178418790HCID 178418790, compound

Product 1

HCID 54247622HCID 54247622, compound

Procedure

A solution of 1-[4-(4-chlorophenyl)-2-(4-aminophenylthio)-n-butyl]imidazole (680 mg) and 1 ml of ethyl)isothiocyanate in 20 ml of tetrahydrofuran was heated overnight under gentle reflux. The solvent was then evaporated and the residue chromatographed on silica gel eluting with 2.2% water in ethyl acetate to give 1-[4-(4-chlorophenyl)-2-(4-ethylaminothiocarbonylaminophenylthio)-n-butyl]imidazole.

Workup

  1. customThe solvent was then evaporated
  2. customthe residue chromatographed on silica gel eluting with 2.2% water in ethyl acetate

Sources & evidence

ORD record
ord-619cc067e7404e9f9bf37db5674b13d5
Source dataset
uspto-grants-1985_05
Patent number
US04518607

Reaction notes

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