1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 896179, compound

HRID 463303Notes

Reaction equation

HRID 463303 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.C(N(CC)CC)C.[CH:24]1([C:27](Cl)=[O:28])[CH2:26][CH2:25]1>ClCCl>[CH:24]1([C:27]([N:12]2[CH2:13][CH2:14][N:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=3)[CH2:10][CH2:11]2)=[O:28])[CH2:26][CH2:25]1

Participants

5

Reactant 3

HCID 42961-(3-(Trifluoromethyl)phenyl)piperazineHCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chloride

Product 1

HCID 896179HCID 896179, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

In 40 ml of dichloromethane, are dissolved 2.3 g (0.01 mole) of 1-(3-trifluoromethylphenyl)piperazine and 1.0 g (0.01 mole) of triethylamine. To the resulting solution, while being cooled and stirred, is added dropwise a solution of 1.05 g (0.01 mole) of cyclopropanecarbonyl chloride in 10 ml of dichloromethane. The mixture is allowed to react at room temperature for 3 hours. The reaction mixture is washed successively with water, dilute hydrochloric acid and water, then dried over anhydrous sodium sulfate, and removed of the solvent by distillation to obtain oily 1-(cyclopropanecarbonyl)-4-(3-trifluoromethylphenyl)piperazine.

Workup

  1. temperatureTo the resulting solution, while being cooled
  2. customto react at room temperature for 3 hours
  3. washThe reaction mixture is washed successively with water, dilute hydrochloric acid and water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customremoved of the solvent by distillation

Sources & evidence

ORD record
ord-a7fe60bc17e04a11a99902a0b6224c0b
Source dataset
uspto-grants-1985_05
Patent number
US04518712

Reaction notes

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