反应详情

A mixture of farnesyl carboxylic acid (5.0 g), farnesol (4.44 g) and triethylamine (4.85 g) was added dropwise at room temperature to a stirred solution of 2-chloro-1-methylpyridinium iodide (5.61 g) in 40 ml of toluene. After complete addition, the reaction mixture was heated on boiled water bath for three hours. After cooling, the mixture was washed with water and dried (Na2SO4). The solvent was removed in vacuo and gave a pale yellow oil. This material was purified by silica gel chromatography by using n-hexane and gave 7.15 g of the titled compound.

1. additionAfter complete addition
2. temperaturethe reaction mixture was heated
3. customfor three hours
4. temperatureAfter cooling
5. washthe mixture was washed with water
6. dry with materialdried (Na2SO4)
7. customThe solvent was removed in vacuo
8. customgave a pale yellow oil
9. customThis material was purified by silica gel chromatography