反应详情

In a three-neck flask equipped with mechanical stirrer, cooled in ice bath under nitrogen atmosphere, place a solution of 4.67 g (0.02 mole) of 4-[(methylsulfonyl)amino]benzoyl chloride in 30 ml of anhydrous THF. Add dropwise a solution of 1.77 g (0.02 mole) of N,N-dimethylethylenediamine in 10 ml of anhydrous THF; white solid precipitate forms immediately. Stir the mixture at ice temperature for one-half hour and at room temperature for one-half hour. Collect the solid by filtration, wash with dichloromethane, and recrystallize from methanol ether mixture to provide the title compound.

1. customIn a three-neck flask equipped with mechanical stirrer
2. temperaturecooled in ice bath under nitrogen atmosphere
3. waitat room temperature for one-half hour
4. customCollect the solid
5. filtrationby filtration
6. washwash with dichloromethane
7. customrecrystallize from methanol ether mixture