(3-Methoxyphenyl)acetic acid → 3-Methoxyphenylacetyl chloride

HRID 463773Notes

Reaction equation

HRID 463773 reaction equation
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[CH3:7][O:8][C:9]1[CH:10]=[C:11](CC(O)=O)[CH:12]=[CH:13][CH:14]=1>C(Cl)Cl>[CH3:7][O:8][C:9]1[CH:14]=[C:13]([CH2:1][C:2]([Cl:4])=[O:3])[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 65578Oxalyl chloride

Product 1

HCID 27332463-Methoxyphenylacetyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (57.1 g) is added to a stirred solution of 3-methoxyphenylacetic acid (49.85 g) in 300 ml of methylene chloride. The reaction mixture is stirred for 11/2 hr at RT, refluxed overnight, and then evaporated in vacuo. The residual product is used in the next step.

Workup

  1. temperaturerefluxed overnight
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-eea52394c43a4fe0b98dbc4262e3de7a
Source dataset
uspto-grants-1985_10
Patent number
US04544670

Reaction notes

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