Magnesium Hydroxide → 2-Hydroxyimino-2-(1,2,5-thiadiazol-3-yl)acetic acid

HRID 463930Notes

Reaction equation

[S:1]1[N:5]=[CH:4][C:3]([C:6](=O)[C:7]([OH:9])=[O:8])=[N:2]1.Cl.[NH2:12][OH:13].[OH-].[Mg+2].[OH-]>>[OH:13][N:12]=[C:6]([C:3]1[CH:4]=[N:5][S:1][N:2]=1)[C:7]([OH:9])=[O:8]

Participants

Reactant 3

HCID 73981Magnesium Hydroxide

HCID 443297Hydroxyamine hydrochloride

HCID 12906559(1,2,5-Thiadiazol-3-yl)glyoxylic acid

Product 1

HCID 1361386132-Hydroxyimino-2-(1,2,5-thiadiazol-3-yl)acetic acidYield 97.1%

Procedure

2-(1,2,5-Thiadiazol-3-yl)glyoxylic acid (7.4 g.) and hydroxylamine hydrochloride (3.1 g.) were reacted in the presence of magnesium hydroxide (4.7 g.) according to a similar manner to that of Example 6(a)(3) to give 2-hydroxyimino-2-(1,2,5-thiadiazol-3-yl)acetic acid (syn isomer) (7.5 g.).

Sources & evidence

ORD record: ord-11440d41eac54ccfb5a022e2ea76c2bd
Source dataset: uspto-grants-1985_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04544751

Reaction notes

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