反应详情

Add 2.0 g (0.0084 mole) of (E)-4-(4-chlorophenyl)-N,N-diethyl-2-buten-1-amine to flask containing 0.20 g platinum (5%) on activated charcoal suspended in 15 ml glacial acetic acid. Stir reaction mixture under one atmosphere hydrogen until hydrogen absorption ceases (41/2 hours). Filter reaction mixture with methylene chloride wash and 50 ml distilled water. Separate layers and extract aqueous with 3×70 ml methylene chloride. Combine methylene chloride extracts and wash with cold 2×75 ml 1N NaOH. Dry organic layer over MgSO4, filter and evaporate to yield the title compound.

1. customuntil hydrogen absorption ceases (41/2 hours)
2. filtrationFilter
3. customreaction mixture with methylene chloride
4. washwash
5. distillation50 ml distilled water
6. extractionSeparate layers and extract aqueous with 3×70 ml methylene chloride
7. washCombine methylene chloride extracts and wash with cold 2×75 ml 1N NaOH
8. filtrationDry organic layer over MgSO4, filter
9. customevaporate