Semicarbazide hydrochloride → HCID 3077560, compound

HRID 464040Notes

Reaction equation

HRID 464040 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2Cl.Cl.[NH2:17][NH:18][C:19]([NH2:21])=[O:20].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]=[C:6]2[NH:17][NH:18][C:19]([NH2:21])=[O:20]

Participants

5

Reactant 3

HCID 11236Semicarbazide hydrochlorideHCID 11430Potassium CarbonateHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 3077560HCID 3077560, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.2 g of 6,7-dimethoxy-4-chloro-quinazoline were dissolved in 50 ml of absolute dimethylformamide, 2.2 g of semicarbazide hydrochloride and 5 g of anhydrous potash were added thereto while stirring. The mixture was stirred for 5 hours at 50° C., and the precipitate formed thereby was suction-filtered off, stirred with water, and then recrystallized from dimethylformamide. The crude product was obtained with a 30% yield; m.p. 247°-249° C.

Workup

  1. stirringThe mixture was stirred for 5 hours at 50° C.
  2. customthe precipitate formed
  3. filtrationthereby was suction-filtered off
  4. stirringstirred with water
  5. customrecrystallized from dimethylformamide

Sources & evidence

ORD record
ord-a734529a52644c1abc75acab3ef2a387
Source dataset
uspto-grants-1985_10
Patent number
US04546102

Reaction notes

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