5-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one → HCID 54538157、化合物

HRID 464340ノート

反応式

HRID 464340 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:6].CS[C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1>N1C=CC=CC=1>[CH3:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

参加物

4

反応物 2

HCID 129459805-(4-Chlorobenzyl)-2-methylthiopyrimid-4-oneHCID 20262876N~1~-Methyl-N~1~-(pyridin-2-yl)propane-1,3-diamine

生成物 1

HCID 54538157HCID 54538157、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.0 g) and 2-methylthio-5-(4-chlorobenzyl)pyrimid-4-one (1.33 g) were heated together under reflux in pyridine (3 ml) for 20 hr. The mixture was stripped and the residue recrystallised twice from ethanol to give 2-[3-(N-methyl-N-pyrid-2-ylamino) propylamino]-5-(4-chlorobenzyl)pyrimid-4-one 0.5H2O. 1.16 g (59%) mp ca. 65° C. (softens).

後処理

  1. customthe residue recrystallised twice from ethanol

出典と根拠

ORDレコード
ord-8606a3887d7548c29ad5e868f49bfa4a
出典データセット
uspto-grants-1985_10
特許番号
US04547506

反応ノート

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