反应详情

A mixture of 4.8 g of the product of Step B, 50 ml of ethyl acetate, 1 ml of quinoline, 1 g of 10% palladium hydroxide on barium sulfate in 50 ml of ethyl acetate was hydrogenated and the mixture was filtered. The filtrate was washed with N hydrochloric acid, then with water, dried and evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and was eluted with a 70-30-1 cyclohexane-ethyl acetate-acetic acid mixture to obtain 3 g of (1R,cis)2,2-dimethyl-3-[Z-2-(pentyloxycarbonyl)ethenyl]-cyclopropane-carboxylic acid.

1. filtrationthe mixture was filtered
2. washThe filtrate was washed with N hydrochloric acid
3. dry with materialwith water, dried
4. customevaporated to dryness under reduced pressure
5. customThe residue was chromatographed over silica gel
6. washwas eluted with a 70-30-1 cyclohexane-ethyl acetate-acetic acid mixture