Phosphorus oxychloride → 2-Amino-5-[3-[3-(piperidinomethyl)phenoxy]propylamino]-1,3,4-oxadiazole

HRID 4645Notes

Reaction equation

HRID 4645 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([NH:18][NH:19][C:20]([NH2:22])=[O:21])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)(Cl)=O>>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:23]=[CH:24][CH:25]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]2[O:21][C:20]([NH2:22])=[N:19][N:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 54294913N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-1,2-hydrazine dicarboxamide

Product 1

HCID 5586752-Amino-5-[3-[3-(piperidinomethyl)phenoxy]propylamino]-1,3,4-oxadiazole

Procedure

The compound is prepared by a method analogous to that of Example 40 from N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-1,2-hydrazine dicarboxamide and phosphorus oxychloride.

Sources & evidence

ORD record
ord-ab50ca1c8ca943ada3827a0b5fa3b8c3
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

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