Hydrochloric Acid → HCID 70481515, compound

HRID 464760Notes

Reaction equation

HRID 464760 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:29]=[CH:28][C:7]([CH2:8][CH2:9][CH:10]2[CH2:14][CH2:13][CH:12]([C:15]3[CH:16]=[CH:17][C:18]4[O:22][C:21]([CH3:24])([CH3:23])[S:20][C:19]=4[CH:25]=3)[N:11]2[CH2:26][OH:27])=[CH:6][CH:5]=1.C(OCC)C>CO>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH2:9][CH:10]2[CH2:14][CH2:13][CH:12]([C:15]3[CH:16]=[CH:17][C:18]4[O:22][C:21]([CH3:24])([CH3:23])[S:20][C:19]=4[CH:25]=3)[N:11]2[CH2:26][OH:27])=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 20262497HCID 20262497, compound

Product 1

HCID 70481515HCID 70481515, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Excess 3% hydrogen chloride in methanol is added to a solution of 1.0 g 2-(p-methoxyphenethyl)-5-(2,2-dimethyl-1,3-benzoxathiol-5-yl)hydroxymethylpyrrolidine in 20 ml of methanol. Diethyl ether is added until precipitation is complete. 2-(p-methoxyphenethyl)-5-(2,2-dimethyl-1,3-benzoxathiol-5-yl)hydroxymethylpyrrolidine hydrochloride is filtered, washed with ether, air dried and recrystallized.

Workup

  1. filtration2-(p-methoxyphenethyl)-5-(2,2-dimethyl-1,3-benzoxathiol-5-yl)hydroxymethylpyrrolidine hydrochloride is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-d09cb85c44b84c6696eaca2ff8fb556d
Source dataset
uspto-grants-1985_10
Patent number
US04548951

Reaction notes

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