反应详情

A solution of 226 g of ethyl cyanoacetate in 200 ml of absolute ethanol is saturated by introducing hydrochloric acid gas at 0°. The mixture is stirred at 0° overnight and then 1.5 l of tert.butyl methyl ether are added thereto. The ethyl β-amino-β-ethoxyacrylate hydrochloride which thereby precipitates is filtered off under suction, washed portionwise with 0.5 l of tert.butyl methyl ether and dried at 35° in vacuo. There is obtained ethyl β-amino-β-ethoxyacrylate hydrochloride, melting point 103°-104°.

1. customThe ethyl β-amino-β-ethoxyacrylate hydrochloride which thereby precipitates
2. filtrationis filtered off under suction
3. washwashed portionwise with 0.5 l of tert.butyl methyl ether
4. customdried at 35° in vacuo