Piperidine → 5-[[2-[[(Cyclohexyl)(methyl)amino]methyl]-1-piperidinyl]-acetyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 465064Notes

Reaction equation

HRID 465064 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[NH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>C(#N)C>[CH:6]1([N:5]([CH2:11][CH:22]2[CH2:23][CH2:24][CH2:25][CH2:26][N:21]2[CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[CH:20][C:6]2=3)=[O:4])[CH3:3])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:7]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 100854195-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 135785625-[[2-[[(Cyclohexyl)(methyl)amino]methyl]-1-piperidinyl]-acetyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared analogously to Example 2 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[[cyclohexyl)(methyl)amino]methyl]piperidine to give colorless crystals, mp. 146°-148° C. (acetonitrile activated charcoal).

Sources & evidence

ORD record
ord-e386a395c5c44078a017f1f5bbe3fa3c
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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