11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → HCID 20261509, compound

HRID 465086Notes

Reaction equation

HRID 465086 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[CH2:21]([N:23]([CH2:31][CH3:32])[CH:24]1[CH2:30][CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1)[CH3:22]>C(O)CC>[CH2:31]([N:23]([CH2:21][CH3:22])[CH:24]1[CH2:30][CH2:29][CH2:28][CH2:27][N:26]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:25]1)[CH3:32]

Participants

4

Reactant 2

HCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 20261498HCID 20261498, compound

Product 1

HCID 20261509HCID 20261509, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

The title compound is prepared analogously to Example 2 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-(diethylamino)-hexahydro-1H-azepine to give colorless crystals, mp. 222°-224° C. (n-propanol).

Sources & evidence

ORD record
ord-1589409e1f444cab8c07572f45653d91
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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