5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one → 5,10-Dihydro-5-[[3-[(1-piperidinyl)methyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 465091Notes

Reaction equation

HRID 465091 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[N:21]1([CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][NH:30][CH2:29]2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>C(OCC)(=O)C>[N:21]1([CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][N:30]([CH2:2][C:3]([N:5]3[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=4[C:9](=[O:16])[NH:8][C:7]4[CH:17]=[CH:18][CH:19]=[CH:20][C:6]3=4)=[O:4])[CH2:29]2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 100854195-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-oneHCID 128029041-[(Piperidin-3-yl)methyl]piperidine

Product 1

HCID 202615305,10-Dihydro-5-[[3-[(1-piperidinyl)methyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound is prepared analogously to Example 35 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 3-[(1-piperidinyl)methyl]piperidine to give colorless crystals, mp. 150°-152° C. (ethyl acetate).

Sources & evidence

ORD record
ord-a57168feb90f49218ee060962f1bb584
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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