反应详情

温度

-10 °C

A mixture of 11.5 g of 2-(ethylthio)-1,4,5,6-tetrahydro-5-pyrimidinol, hydrobromide, 2.5 ml of hydrazine hydrate and 50 ml of ethanol was stirred at reflux for 5 hours, taken to dryness in vacuo and suspended in 100 ml of 2-propanol at the boil. A 100 ml portion of methanol was added at the boil, then the solution was clarified and cooled to -10° C., giving 4.9 g of the desired intermediate, mp 163°-164° C.

1. temperatureat reflux for 5 hours