反应详情

A mixture of 4.989 g of [(8-acetyl-7-hydroxy-2-naphthalenyl)oxy]acetic acid methyl ester, 18 ml of 1,3-dibromopropane and 3.7 g of anhydrous potassium carbonate in 150 ml of anhydrous acetone was stirred at reflux for 16.5 hours. The reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was chromatographed on 250 g of silica gel. Elution with 10% ethyl acetate-toluene gave 6.730 g (95% yield) of [[8-acetyl-7-(3-bromopropoxy)-2-naphthalenyl]oxy]acetic acid methyl ester as an oil.

1. temperatureat reflux for 16.5 hours
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated in vacuo
4. customThe residue was chromatographed on 250 g of silica gel
5. washElution with 10% ethyl acetate-toluene