Hydrogen Peroxide → 4-(1,1-Difluoroethyl)benzamide

HRID 46536Notes

Reaction equation

HRID 46536 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][CH:6]=1)([F:4])[F:3].[OH:13]O.[OH-].[Na+]>>[F:4][C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH2:12])=[O:13])=[CH:7][CH:6]=1)([F:3])[CH3:1]

Participants

4

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 671815214-(1,1-Difluoroethyl)benzonitrile

Product 1

HCID 674934594-(1,1-Difluoroethyl)benzamide

Procedure

5 gm of p-CH3CF2C6H4CN, 200 ml of an aqueous solution of H2O2 at 3% and 10 ml of an aqueous solution of NaOH at 25% were reacted at 60° C. during 4 hours. A white precipitate was progressively formed. The reaction medium was then cooled, filtered, washed with water and dried under vacuum. 5.5 gm of ##STR45## were obtained.

Workup

  1. customA white precipitate was progressively formed
  2. temperatureThe reaction medium was then cooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried under vacuum
  6. custom5.5 gm of ##STR45## were obtained

Sources & evidence

ORD record
ord-714ecd5576f44734ae815878060a6599
Source dataset
uspto-grants-1979_11
Patent number
US04173706

Reaction notes

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