Hydrochloric Acid → HCID 67915647, compound

HRID 465377Notes

Reaction equation

HRID 465377 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:31])[C:19]([C:28]([OH:30])=[O:29])=[CH:20][N:21]3[CH:25]3[CH2:27][CH2:26]3)=[C:16]([NH2:32])[C:15]=2[F:33])[CH2:9]1)=O)(C)(C)C.[ClH:34]>C(O)(=O)C>[ClH:34].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:31])[C:19]([C:28]([OH:30])=[O:29])=[CH:20][N:21]3[CH:25]3[CH2:27][CH2:26]3)=[C:16]([NH2:32])[C:15]=2[F:33])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15021549HCID 15021549, compound

Product 1

HCID 67915647HCID 67915647, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

7-(t-Butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-5-amino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (105 mg), 0 5 ml of concentrated hydrochloric acid and 2 xl of acetic acid were used. The compound was treated in a similar manner to Example 1-(2) and recrystallized from ethanol, whereby 82 mg of the title compound was obtained.

Workup

  1. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-3900ce22f2204b039c24888fd7b3b878
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

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