Sodium hydride → HCID 15021590, compound

HRID 465391Notes

Reaction equation

HRID 465391 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([NH2:16])[CH:10]=[C:11](F)[C:12]=3[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]2)[CH2:3][CH2:2]1.[NH:21]1[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23][CH2:22]1.[H-].[Na+]>>[NH:21]1[CH2:26][CH2:25][CH:24]([O:27][C:11]2[C:12]([F:14])=[C:13]3[C:8]([C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5][N:4]3[CH:1]3[CH2:3][CH2:2]3)=[C:9]([NH2:16])[CH:10]=2)[CH2:23][CH2:22]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 79341Piperidin-4-olHCID 15021589HCID 15021589, compound

Product 1

HCID 15021590HCID 15021590, compound

Procedure

1-Cyclopropyl-5-amino-7,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 4-piperidinol and sodium hydride were reacted and treated in a similar manner to Example 9, whereby the title compound was obtained as colorless powder.

Sources & evidence

ORD record
ord-9ccc395e383d4504bf33da80afcc6fe1
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

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