反应详情

Sodium (0.68 g, 29.5 mmol, Aldrich lot #9621CL) was added in portions to anhydrous ethanol (50 mL). Upon complete dissolution 2-amino-6-chloropurine (1 g, 5.9 mmol Sigma lot #69F4064) was added and the reaction heated at reflux for 96 hours. The reaction was cooled, diluted with 20 mL water, and neutralized with 1N HCl. The solvents were evaporated and the residue slurried in 100 mL water. The product was filtered off and air dried to give 0.95 g (5.3 mmol; 89.9%); mp=252-°253° C.

1. additionwas added
2. temperaturethe reaction heated
3. temperatureat reflux for 96 hours
4. temperatureThe reaction was cooled
5. customThe solvents were evaporated
6. filtrationThe product was filtered off
7. customair dried
8. customto give 0.95 g (5.3 mmol; 89.9%)
9. custommp=252-°253° C.