1-Butanol → HCID 178450382, compound

HRID 465718Notes

Reaction equation

HRID 465718 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[Na].[CH2:13]([OH:17])[CH2:14][CH2:15][CH3:16]>>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([O:17][CH2:13][CH2:14][CH2:15][CH3:16])[N:3]=1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 53603492-Amino-6-chloropurineHCID 5360545Sodium

Product 1

HCID 178450382HCID 178450382, compound

Procedure

The title compound was prepared in a manner analogous to the preparation of the compound of Example 11a, using 2-amino-6-chloropurine (Sigma, lot #69F4064, 4.4 g, 25.9 mmol) and sodium (Aldrich, lot #9621CL, 3 g, 129.5 mmol) in 250 mL n-butanol to give 4.4 g (21.2 mmol, 82%). mp=165° C.

Workup

  1. customto give 4.4 g (21.2 mmol, 82%)

Sources & evidence

ORD record
ord-1ab72dc2274a4002977c1440e3ec603b
Source dataset
uspto-grants-1992_10
Patent number
US05153318

Reaction notes

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