Pyrrolidine → HCID 178508573, compound

HRID 465726Notes

Reaction equation

HRID 465726 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[N:3]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 53603492-Amino-6-chloropurine

Product 1

HCID 178508573HCID 178508573, compound

Procedure

2-Amino-6-chloropurine (Sigma, lot #69F4064, 5.0 g, 29.5 mmol) was stirred in pyrrolidine (Kodak, lot #B161, 30mL) at 80° C. for 24 hours. The solvent was evaporated to a gold solid which was recrystalized from methanol to yield 3.41 g (16.7 mmol, 58%); mp=265°C.

Workup

  1. customThe solvent was evaporated to a gold solid which
  2. customwas recrystalized from methanol
  3. customto yield 3.41 g (16.7 mmol, 58%)

Sources & evidence

ORD record
ord-c79a1b2e75144d2d8ae55a4c5112e3d8
Source dataset
uspto-grants-1992_10
Patent number
US05153318

Reaction notes

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