Sodium hydride → HCID 19814836, compound

HRID 465881Notes

Reaction equation

HRID 465881 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][C:11]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]3[N:26]=[C:25]([O:27][CH3:28])[CH:24]=[C:23]([O:29][CH3:30])[N:22]=3)[C:12]=2[C:13]([OH:15])=[O:14])[N:3]=1.[H-].[Na+].ClC[CH2:35][C:36]([CH3:41])([CH3:40])[C:37]([O-:39])=[O:38].[CH2:42](O)C.CCCCCC>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][C:11]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][C:21]3[N:22]=[C:23]([O:29][CH3:30])[CH:24]=[C:25]([O:27][CH3:28])[N:26]=3)[C:12]=2[C:13]([O:15][CH2:42][O:39][C:37](=[O:38])[C:36]([CH3:41])([CH3:40])[CH3:35])=[O:14])[N:3]=1

Participants

6

Reactant 4

HCID 24758Sodium hydrideHCID 14648844HCID 14648844, compoundHCID 217530474-Chloro-2,2-dimethylbutanoateHCID 21879635Ethanol hexane

Product 1

HCID 19814836HCID 19814836, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.9 g of (2.1 mmol) of 2-(4-chloro-6-methoxypyrimidin -2-yl)oxy-6-(4,6-dimethoxypyrimidin-2-yl) oxybenzoic acid, 0.1 g of 60% sodium hydride and 0.39 g (2.5 mmol) of chloromethylpivalate were reacted in N,N-dimethylformamide, treated and purified in the same manner as in Example 1. To the residue thus obtained, were added ethanol/hexane to precipitate a solid, which was filtered out to obtain 0.6 g of a white crystal having a melting point of from 83° to 85° C.

Workup

  1. additiontreated
  2. custompurified in the same manner as in Example 1
  3. customTo the residue thus obtained
  4. customto precipitate a solid, which
  5. filtrationwas filtered out

Sources & evidence

ORD record
ord-39df2011bd2f49159d80434f05607576
Source dataset
uspto-grants-1992_10
Patent number
US05154750

Reaction notes

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