Sodium hydride → HCID 19814837, compound

HRID 465882Notes

Reaction equation

HRID 465882 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[N:27]=[C:26]([O:28][CH3:29])[CH:25]=[C:24]([O:30][CH3:31])[N:23]=3)[C:13]=2[C:14]([OH:16])=[O:15])[N:4]=1.[H-].[Na+].Cl[CH2:35][S:36][CH2:37]Cl>CN(C)C=O>[CH3:29][O:28][C:26]1[CH:25]=[C:24]([O:30][CH3:31])[N:23]=[C:22]([O:21][C:17]2[CH:18]=[CH:19][CH:20]=[C:12]([O:11][C:5]3[N:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[N:6]=3)[C:13]=2[C:14]([O:16][CH2:35][S:36][C:37]2[CH:19]=[CH:20][CH:12]=[CH:13][CH:14]=2)=[O:15])[N:27]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 443031BispyribacHCID 565560Bis(chloromethyl) sulfide

Product 1

HCID 19814837HCID 19814837, compoundYield 126.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.7 g (4.0 mmol) of 2,6-bis[(4,6-dimethoxypyrimidin-2-yl) oxy]benzoic acid, 0.2 g of 60% sodium hydride and 0.72 g (4.4 mmol) of chloromethylsulfide were reacted in N,N-dimethylformamide, treated and purified in the same manner as in Example 1 to obtain 1.4 g of a white crystal having a melting point of from 89° to 93° C.

Workup

  1. additiontreated
  2. custompurified in the same manner as in Example 1

Sources & evidence

ORD record
ord-ab68ba3ef5134395b83832bbfd312b2c
Source dataset
uspto-grants-1992_10
Patent number
US05154750

Reaction notes

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