反应详情

A mixture, cooled to 0°-5° C., of 45 g of 4-methanesulphonyl-2,2-dimethylpiperazine, 19.3 g of sodium nitrite, 250 ml of water and 100 ml of methanol is adjusted to pH 1.0 using conc. HCl and stirred at a gradually increasing temperature for 12 hours. The precipitate is filtered off with suction, washed with water and dried in vacuo.

1. temperaturea gradually increasing temperature for 12 hours
2. filtrationThe precipitate is filtered off with suction
3. washwashed with water
4. customdried in vacuo