Hydrochloric Acid → 2,2-Dimethyl-4-(methylsulfonyl)-1-nitrosopiperazine

HRID 465925Notes

Reaction equation

HRID 465925 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][NH:8][C:7]([CH3:12])([CH3:11])[CH2:6]1)(=[O:4])=[O:3].[N:13]([O-])=[O:14].[Na+].O.Cl>CO>[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([N:13]=[O:14])[C:7]([CH3:12])([CH3:11])[CH2:6]1)(=[O:3])=[O:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 198151421-Methanesulfonyl-3,3-dimethylpiperazineHCID 23668193Sodium Nitrite

Product 1

HCID 198151462,2-Dimethyl-4-(methylsulfonyl)-1-nitrosopiperazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture, cooled to 0°-5° C., of 45 g of 4-methanesulphonyl-2,2-dimethylpiperazine, 19.3 g of sodium nitrite, 250 ml of water and 100 ml of methanol is adjusted to pH 1.0 using conc. HCl and stirred at a gradually increasing temperature for 12 hours. The precipitate is filtered off with suction, washed with water and dried in vacuo.

Workup

  1. temperaturea gradually increasing temperature for 12 hours
  2. filtrationThe precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-1a5f840b5d8c4f4397db40ac7039863c
Source dataset
uspto-grants-1992_10
Patent number
US05155109

Reaction notes

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