Benzoyl chloride → HCID 14049603, compound

HRID 466149Notes

Reaction equation

HRID 466149 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[C:9]([OH:11])[C:8]([Cl:12])=[CH:7][N:6]=1)(=[O:3])[CH3:2].[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)CC)C>C(#N)C>[C:1]([O:4][C:5]1[CH:10]=[C:9]([O:11][C:13](=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]([Cl:12])=[CH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 178475520HCID 178475520, compound

Product 1

HCID 14049603HCID 14049603, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The general procedure of Example 21 was followed using 200 mg of 2-acetoxy-5-chloro-4-hydroxypyridine, 0.15 ml of benzoyl chloride and 0.74 ml of triethylamine and 20 ml of acetonitrile, thereby giving 300 mg of the title compound in a yield of 96%.

Sources & evidence

ORD record
ord-58ddfc3ee6b044f7a436644cc9ffef0d
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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