Benzoyl chloride → HCID 14049687, compound

HRID 466150Notes

Reaction equation

HRID 466150 reaction equation
[Cl:1][C:2]1[C:3]([OH:13])=[CH:4][C:5](=[O:12])[N:6]([CH2:8][O:9][CH2:10][CH3:11])[CH:7]=1.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C>O1CCOCC1>[C:14]([O:13][C:3]1[C:2]([Cl:1])=[CH:7][N:6]([CH2:8][O:9][CH2:10][CH3:11])[C:5](=[O:12])[CH:4]=1)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 54734184HCID 54734184, compound

Product 1

HCID 14049687HCID 14049687, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The general procedure of Example 49 was followed using 200 mg of 5-chloro-1-ethoxymethyl-4-hydroxy-2-pyridone, 0.14 ml of benzoyl chloride, 0.68 ml of triethylamine and 20 ml of dioxane, thereby producing 280 mg of the title compound in a yield of 93%.

Sources & evidence

ORD record
ord-e6f766f92ac9417a9ee7f0f7b50cae28
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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