反应详情

A mixture of 4-[3-[(2-hydroxyethyl)amino]propoxy]benzonitrile (3 g), 1-bromo-3-(propylthio)propane (2.7 g) and potassium carbonate (3.7 g) in 2-propanol (50 ml) was refluxed for 28 hours. The solvent was evaporated and the residue dissolved in aqueous HCl (2 M) and extracted with diethylether. The aqueous layer was basified with sodium hydroxide (10 M) and extracted with methylene chloride followed by drying over sodium sulfate. Evaporation of the solvent gave a crude residue, which was purified by column chromatography. Yield 2.6 g of the title compound as an oil.

1. temperaturewas refluxed for 28 hours
2. customThe solvent was evaporated
3. dissolutionthe residue dissolved in aqueous HCl (2 M)
4. extractionextracted with diethylether
5. extractionextracted with methylene chloride
6. dry with materialby drying over sodium sulfate
7. customEvaporation of the solvent