Hydrochloric Acid → HCID 19762862, compound

HRID 466249Notes

Reaction equation

HRID 466249 reaction equation
[CH2:1]([CH:4]([CH2:7][CH2:8][CH3:9])[CH2:5][OH:6])[CH2:2][CH3:3].[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](O)(=[O:18])=[O:17])=[CH:12][CH:11]=1.N1C=CC=CC=1.Cl>C(Cl)(Cl)Cl>[S:16]([C:13]1[CH:14]=[CH:15][C:10]([CH3:20])=[CH:11][CH:12]=1)([O:6][CH2:5][CH:4]([CH2:7][CH2:8][CH3:9])[CH2:1][CH2:2][CH3:3])(=[O:18])=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 6101p-Toluenesulfonic acidHCID 1235431-Pentanol, 2-propyl-

Product 1

HCID 19762862HCID 19762862, compoundYield 96.9%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a mixture of 52 g 2-propylpentanol and 86 g of p-toluenesulfonic acid in 175 ml of chloroform was added at 0°-3° C. and under N2 -atmosphere 48 g of pyridine. The mixture was kept at 0° C. for 30 minutes and at room temperature for 19 hrs. After cooling the reaction mixture, 3M HCl (300 ml) was added. The organic phase was separated and washed with water and rine. Drying with Na2SO4 and evaporation gives 110 g of 2-propylpentyl tosylate.

Workup

  1. additionwas added
  2. customThe organic phase was separated
  3. washwashed with water and rine
  4. dry with materialDrying with Na2SO4 and evaporation

Sources & evidence

ORD record
ord-cd54112771b740988c288c81990149ef
Source dataset
uspto-grants-1992_10
Patent number
US05155220

Reaction notes

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