4-Aminophenol → Acetaminophen

HRID 466309Notes

Reaction equation

[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH:8]1[C:13]([NH2:14])=[CH:12][CH:11]=[C:10]([OH:15])[CH:9]=1>>[C:1]([NH:14][C:13]1[CH:12]=[CH:11][C:10]([OH:15])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 4034-Aminophenol

HCID 7918Acetic Anhydride

Product 1

HCID 1983Acetaminophen

Procedure

A process as set forth in claim 1 wherein the improvement further comprises reacting acetic anhydride with the p-aminophenol contained in said purified raffinate to produce N-acetyl-p-aminophenol, and recovering N-acetyl-p-aminophenol from the acetylation reaction mixture.

Workup

customin said purified raffinate

Sources & evidence

ORD record: ord-ccd477af53be423dbea1dd198531e9c1
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05155269

Reaction notes

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