Bromine → 2-Bromo-6-chloro-1-tetralone

HRID 46632Notes

Reaction equation

HRID 46632 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[Br:13]Br>C(OCC)(=O)C>[Br:13][CH:7]1[CH2:6][CH2:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=2)[C:8]1=[O:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 122911496-Chloro-1-tetralone

Product 1

HCID 203864882-Bromo-6-chloro-1-tetralone

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5 g of 6-chloro-1-tetralone are reacted with 4.4 g of bromine in ethyl acetate analogously to the instructions indicated in Example 29 (a). After distilling off the solvent under reduced pressure, 2-bromo-6-chloro-1-tetralone is obtained as an amorphous residue, which is used without further purification.

Workup

  1. distillationAfter distilling off the solvent under reduced pressure

Sources & evidence

ORD record
ord-9afeabfb0de946a896d15fcb22c8c879
Source dataset
uspto-grants-1979_11
Patent number
US04174397

Reaction notes

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