Ammonia → 2,6-Difluoro-4-methoxybenzamide

HRID 466490Notes

Reaction equation

HRID 466490 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4](Cl)=[O:5].[NH3:14]>COCCOCCOC>[F:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4]([NH2:14])=[O:5]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

Product 1

HCID 27787702,6-Difluoro-4-methoxybenzamide

Reagents, catalysts & solvents 1

HCID 8150DiglymeSolvent

Procedure

The crude acid chloride (25) was dissolved in dry diglyme (60 ml) and added dropwise at room temperature with gentle stirring to 35% ammonia (750 ml). The resulting colourless precipitate was filtered off and dried (CaCl2) in vacuo to give a colourless solid.

Workup

  1. additionadded dropwise at room temperature
  2. filtrationThe resulting colourless precipitate was filtered off
  3. dry with materialdried (CaCl2) in vacuo
  4. customto give a colourless solid

Sources & evidence

ORD record
ord-44569574662a42a0b3a3d9eed2e3c01e
Source dataset
uspto-grants-1992_10
Patent number
US05156763

Reaction notes

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