反应详情

A solution of 1-bromobutane (18.0 g, 0.13 mol) in acetone (30 ml) was added dropwise to a stirred refluxing mixture of 2-fluoro-4-hydroxybenzonitrile (15.0 g, 0.11 mol) and potassium carbonate (46.0 g, 0.33 mol) in acetone (300 ml). The stirred mixture was heated under reflux for 21 h (glc analysis revealed absence of starting material). The product was extracted into ether (twice), and the combined ethereal extracts were washed with water, 5% sodium hydroxide, water and dried (MgSO4). The solvent and the excess of 1-bromobutane were removed in vacuo to yield a pale-orange solid.

1. temperaturerefluxing
2. temperatureThe stirred mixture was heated
3. temperatureunder reflux for 21 h (glc analysis revealed absence of starting material)
4. extractionThe product was extracted into ether (twice), and the combined ethereal extracts
5. washwere washed with water, 5% sodium hydroxide, water
6. dry with materialdried (MgSO4)
7. customThe solvent and the excess of 1-bromobutane were removed in vacuo
8. customto yield a pale-orange solid