Ethyl formate → HCID 19814509, compound

HRID 466589Notes

Reaction equation

HRID 466589 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH2:10]([O:12]C=O)C>>[CH3:9][O:8][C:5]1[CH:4]=[CH:3][C:2]([NH:1][CH:10]=[O:12])=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 811216-Methoxy-3-pyridinylamine

Product 1

HCID 19814509HCID 19814509, compound

Procedure

5-Amino-2-methoxy pyridine (25 g, 0.2 mol) was added to ethylformate (50 ml). This solution was refluxed for eight hours. The volatiles were removed on a rotary evaporator at 30° C. and at aspirator vacuum. The resultant product was pink solid, 30.2 g, 99% of theory, m.p. 81°-83° C. The structure was confirmed by mass spectroscopy (MS), infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy.

Workup

  1. temperatureThis solution was refluxed for eight hours
  2. customThe volatiles were removed on a rotary evaporator at 30° C. and at aspirator vacuum

Sources & evidence

ORD record
ord-caa1370c6e924091b5085ec6407271e0
Source dataset
uspto-grants-1992_10
Patent number
US05157043

Reaction notes

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