反应详情

温度

-78 °C

To a cooled (-78° C.) stirred solution of 6-bromo-2-butyl-7-methylimidazo[4,5-b]pyridine (98 mg, 0.366 mmol) in THF (4 mL) was added tert-butyllithium (0.86 mL of a 1.7M solution in pentane, 1.46 mmol). After 15 minutes, MeOH (0.5 mL and brine were added the mixture was warmed to room temperature and extracted with EtOAc (4×10 mL). Drying (K2CO3), concentration, and purification (SiO2, 100% EtOAc) gave 60 mg (87%) of the title compound as an oil.

1. temperaturewas warmed to room temperature
2. extractionextracted with EtOAc (4×10 mL)
3. customDrying
4. concentration(K2CO3), concentration, and purification (SiO2, 100% EtOAc)