HCID 178435160, compound → Ammonium Hydroxide

HRID 466824Notes

Reaction equation

HRID 466824 reaction equation
[Si]([O:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH3:20])[CH:18]=2)[N:13]=[C:12]([CH2:21][CH2:22][CH3:23])[C:11]=1[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:37]2[NH:41][N:40]=[N:39][N:38]=2)=[CH:27][CH:26]=1)(C(C)(C)C)(C)C>C(Cl)(Cl)Cl>[NH4+:13].[OH-:8].[OH:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH3:20])[CH:18]=2)[N:13]=[C:12]([CH2:21][CH2:22][CH3:23])[C:11]=1[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=2[C:37]2[NH:41][N:40]=[N:39][N:38]=2)=[CH:27][CH:26]=1

Participants

5

Reactant 2

HCID 178435160HCID 178435160, compoundHCID 178439890HCID 178439890, compound

Product 2

HCID 14923Ammonium HydroxideHCID 178439889HCID 178439889, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 10 mg of 57 in 100 λ CHCl3 in a polyethylene mini-centrifuge tube was added ~0.1 ml 48% aq. HF. The two-phase mix was vigorously stirred for two hours, then evaporated to dryness under a nitrogen stream. Preparative tlc of the residue on silica gel GF with 2:20:80 NH4OH:MeOH:CHCl3 afforded the title compound.

Workup

  1. additionThe two-phase mix
  2. customevaporated to dryness under a nitrogen stream

Sources & evidence

ORD record
ord-26d131090f094fe89eeaf3804b2cc261
Source dataset
uspto-grants-1992_10
Patent number
US05157040

Reaction notes

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