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HRID4669

反应详情

EQUATION

反应方程式

HRID 4669 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)CC(C)=O
HCID7757

Methyl acetoacetate

C5H8O3

结构：COC(=O)/C=C(/C)N
HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：O=Cc1cc([N+](=O)[O-])ccc1OC/C=C/CCl
HCID14050496

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cc([N+](=O)[O-])ccc1OC/C=C/CCl
HCID14050497

未命名化合物

收率 48.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

5.2 g of 2-[(E)-4-chloro-2-butenyloxy]-5-nitrobenzaldehyde, 2.4 g of methyl acetoacetate and 2.3 g of methyl 3-aminocrotonate was dissolved in 30 ml of iso-propanol, and the solution obtained was refluxed for 3.5 hours under heating. After cooling, the precipitated crystals were collected by filtration to give 4.4 g of dimethyl 4-[2-[(E)-4-chloro-2-butenyloxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. (mp. 206°-207° C.). The product obtained was used directly for the next process without purification.

WORKUP

后处理

  1. customthe solution obtained
  2. temperaturewas refluxed for 3.5 hours
  3. temperatureunder heating
  4. temperatureAfter cooling
  5. filtrationthe precipitated crystals were collected by filtration