反应详情

To a stirred and chilled (0°) solution containing 200 g (0.86 mol) of 2-bromo-4-nitrophenylhydrazine (m.p. 143°-145°) and 116.8 g (0.9 mol) of ethyldiisopropylamine in 1000 ml of tetrahydrofuran was added dropwise 108.5 g (0.9 mol) of pivaloyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour and then concentrated to dryness under reduced pressure. The residue was treated with water, filtered and recrystallized from ethanol to give 165 g (52%) of product as a light yellow solid; m.p. 145° C.

1. temperaturechilled (0°) solution
2. stirringThe reaction mixture was stirred at ambient temperature for 1 hour
3. concentrationconcentrated to dryness under reduced pressure
4. additionThe residue was treated with water
5. filtrationfiltered
6. customrecrystallized from ethanol