反应详情

温度

0 °C

To a stirred and chilled (0° C.) solution containing 25 g (0.133 mol) of 2-chloro-4-nitrophenylhydrazine and 18.06 g (0.14 mol) of ethyldiisopropylamine in 200 ml of tetrahydrofuran was added dropwise 16.75 g (0.139 mol) of pivaloyl chloride. The reaction mixture was briefly heated to reflux and then concentrated under reduced pressure. The residue was treated with water, filtered and dried to give 32.5 g (90% yield) of the desired product as a yellowish solid; m.p. 123° C.

1. temperatureThe reaction mixture was briefly heated
2. temperatureto reflux
3. concentrationconcentrated under reduced pressure
4. additionThe residue was treated with water
5. filtrationfiltered
6. customdried