反应详情

温度

100 °C

A solution of (50 g, 0.22 mole) of 2'-deoxyuridine and 62 g (0.22 mole) of trityl chloride in 350 ml of dry pyridine was placed in a preheated (100° C.) flask and stirred at 100° C. under an air condenser for two hours. The reaction mixture was cooled to room temperature and slowly poured into 4 L of vigorously stirred ice-water. The solid obtained was filtered, washed with water until free from pyridine, and dissolved in chloroform and dried (Na2SO4 or MgSO4). Filtration and evaporation of chloroform yielded the 5'-O-trityl-2'-deoxyuridine product as an syrup (96 g, 93%), which was used for the next reaction without further purification.

1. customwas placed in a preheated (100° C.) flask
2. temperatureThe reaction mixture was cooled to room temperature
3. customThe solid obtained
4. filtrationwas filtered
5. washwashed with water until free from pyridine
6. dissolutiondissolved in chloroform
7. dry with materialdried (Na2SO4 or MgSO4)
8. filtrationFiltration and evaporation of chloroform