反应详情

Benzo[b]thiophene-2-ylboronic acid (884 mg, 5.0 mmol) and 9-chlorophenanthridin (1.0 g, 4.8 mmol) were dissolved in tetrahydrofuran (30 ml), and palladium catalyst (160 mg, 0.14 mmol) and 2M sodium carbonate solution (20 ml) were added, followed by refluxing under a N2 atmosphere for 5 hours. The reaction solution was added to H2O and the mixture was extracted with chloroform, followed by drying with sodium sulfate. After filtration, the filtrate was evaporated to dryness under reduced pressure. The obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%).

1. temperatureby refluxing under a N2 atmosphere for 5 hours
2. extractionthe mixture was extracted with chloroform
3. dry with materialby drying with sodium sulfate
4. filtrationAfter filtration
5. customthe filtrate was evaporated to dryness under reduced pressure
6. customThe obtained solid was purified by column chromatography (eluent: chloroform) (amount: 1.15 g, yield: 78%)