反应详情

0.303 g of sodium acetate, 0.375 g of formaldehyde and 0.218 g of sodium cyanoborohydride are added to a solution of 0.5 g of tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate in 50 ml of MeOH and stirred for 1 hour at RT. A saturated solution of NaHCO3 is added, it is extracted with DCM, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is chromatographed on silica gel, eluting with DCM/MeOH mixture. 0.31 g of the expected compound is obtained.

1. extractionit is extracted with DCM
2. dry with materialthe organic phase is dried over Na2SO4
3. customthe solvent is evaporated under vacuum
4. customThe residue is chromatographed on silica gel
5. washeluting with DCM/MeOH mixture