Potassium Carbonate → HCID 70922455, compound

HRID 467524Notes

Reaction equation

HRID 467524 reaction equation
C([O-])([O-])=O.[K+].[K+].C([N:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([CH3:19])[CH:17]=2)[C:12]([C:20]([NH:22][C:23]2[CH:28]=[CH:27][C:26]([N:29]3[C:33]([CH3:34])=[C:32]([C:35](=[O:39])[CH2:36][CH2:37][CH3:38])[CH:31]=[N:30]3)=[CH:25][CH:24]=2)=[O:21])=[CH:11]1)(=O)C>CCOC(C)=O.CO>[C:35]([C:32]1[CH:31]=[N:30][N:29]([C:26]2[CH:27]=[CH:28][C:23]([NH:22][C:20]([C:12]3[C:13]4[C:18](=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=4)[NH:10][CH:11]=3)=[O:21])=[CH:24][CH:25]=2)[C:33]=1[CH3:34])(=[O:39])[CH2:36][CH2:37][CH3:38]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 123139069HCID 123139069, compound

Product 1

HCID 70922455HCID 70922455, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

1.5 g of K2CO3 is added to a solution of 1.15 g of the compound from step 1 in 40 ml of MeOH/THF mixture (50/50; v/v) and stirred for 4 hours at RT. The reaction mixture is concentrated under vacuum, the residue is taken up in EtOAc/water mixture, the organic phase is washed with water, with saturated NaCl solution, dried over Na2SO4 and the solvent is evaporated under vacuum. The residue is taken up in iso ether and the precipitate that formed is drained. 0.9 g of the expected compound is obtained.

Workup

  1. concentrationThe reaction mixture is concentrated under vacuum
  2. washthe organic phase is washed with water, with saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customthe solvent is evaporated under vacuum
  5. customthe precipitate that formed

Sources & evidence

ORD record
ord-12184d5882874ba98609d6b6778ee4fb
Source dataset
uspto-grants-2014_01
Patent number
US08623862B2

Reaction notes

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