4-Bromo-2,5-dimethylbenzene-1-sulfonamide → 4-Cyano-2,5-dimethylbenzenesulfonamide

Temperature

200 °C

To a solution of 4-bromo-2,5-dimethylbenzenesulfonamide (4.6 g, 22 mmol, the product of Step A) in N-methylpyrrolidinone (30 mL) was added copper cyanide (2.5 g, 28 mmol), and the reaction mixture was heated at 200° C. for 30 min. The reaction was then allowed to cool and poured into 200 mL of crushed ice to precipitate a solid. To this mixture was added dichloromethane (500 mL), and the mixture was warmed to dissolve the white solid. The mixture was then filtered to remove any undissolved solids, the phases were separated, and the dichloromethane was washed with water (2×100 mL), dried over magnesium sulfate, and evaporated under reduced pressure to obtain an oil. The oil was dissolved in tetrahydrofuran (30 mL) and water (30 mL), and the solution was concentrated under reduced pressure to precipitate a solid. This solid was isolated by filtration and washed with water to afford 2.5 g of the title compound. 1H NMR (CDCl3) δ 7.98 (s, 1H), 7.56 (s, 1H), 4.89 (br s, 2H), 2.66 (s, 3H), 2.58 (s, 3H).

1. temperatureto cool
2. customto precipitate a solid
3. additionTo this mixture was added dichloromethane (500 mL)
4. temperaturethe mixture was warmed
5. dissolutionto dissolve the white solid
6. filtrationThe mixture was then filtered
7. customto remove any undissolved solids
8. customthe phases were separated
9. washthe dichloromethane was washed with water (2×100 mL)
10. dry with materialdried over magnesium sulfate
11. customevaporated under reduced pressure
12. customto obtain an oil
13. concentrationwater (30 mL), and the solution was concentrated under reduced pressure
14. customto precipitate a solid
15. customThis solid was isolated by filtration
16. washwashed with water

ORD record

ord-28778c4adc414d54b42d632684500418

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08623890B2