Diisopropylamine → HCID 66795388, compound

Temperature

-20 °C

Step 1—A solution of n-butyl lithium in hexane (1.4M, 16.9 mL, 0.09 mol) was added drop wise to a solution of freshly distilled diisopropylamine (3.1 mL, 0.02 mol) in dry THF (20 mL) at −60° C. under a nitrogen atmosphere. The reaction mixture was slowly warmed to −20° C. and stirred for 30 min. The reaction mixture was re-cooled to −60° C. and cyclopropanecarboxylic acid tert-butyl ester (3.1 g, 0.02 mol) was added drop wise over a period of 10 min. The reaction mixture was slowly warmed to −20° C. and stirred for 30 min. To the re-cooled (−60° C.) above reaction mixture was added drop wise 1,8-dibromoctane (2.0 g, 7.0 mmol) in dry THF (5 mL) and DMPU (0.46 mL, 3.2 mmol). Then, the temperature was allowed to reach room temperature and stirred at the same temperature over a period of 16 hours. The resulting reaction mixture was quenched with saturated NH4Cl (50 mL) at 0° C. and the reaction mixture extracted with ether (50 mL×3). The organic phases were combined, dried over anhydrous Na2SO4 and volatiles evaporated under reduced pressure to yield a pale, yellow liquid which was filtered through a silica gel (230-400) column (1.5% ethyl acetate in pet ether) to yield 1.96 g of a crude (70%) colorless oil. The compound was taken to the next step without further purification or characterization.

1. temperatureThe reaction mixture was re-cooled to −60° C.
2. temperatureThe reaction mixture was slowly warmed to −20° C.
3. stirringstirred for 30 min
4. temperatureTo the re-cooled (−60° C.)
5. customabove reaction mixture
6. customto reach room temperature
7. stirringstirred at the same temperature over a period of 16 hours
8. customThe resulting reaction mixture
9. customwas quenched with saturated NH4Cl (50 mL) at 0° C.
10. extractionthe reaction mixture extracted with ether (50 mL×3)
11. dry with materialdried over anhydrous Na2SO4 and volatiles
12. customevaporated under reduced pressure
13. customto yield a pale, yellow liquid which
14. filtrationwas filtered through a silica gel (230-400) column (1.5% ethyl acetate in pet ether)

ORD record

ord-d673d3e2fae14167b8f26032a062649f

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08623897B2